Table 2 |
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|
Comparison of the baseline and the change in hand bone mineral density |
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|
Disease duration |
DAS28 at baseline |
MHAQ at baseline |
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|
|
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|
≤3 years |
>3 years |
P value* |
<3.2 |
3.2–5.1 |
>5.1 |
P value |
<1.50 |
1.50–1.99 |
≥2.0 |
P value |
|
|
|
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|
n |
37 |
178 |
<0.01 |
55 |
103 |
44 |
<0.01 |
102 |
78 |
34 |
<0.01 |
|
Age (years) |
55.4 (43–62) |
58.0 (50–65) |
0.10 |
53.5 (39–61) |
55.8 (49–64) |
62.2 (57–67) |
<0.01 |
53.6 (41–64) |
58.9 (52–64) |
61.2 (54–67) |
<0.01 |
|
DXA-BMD (g/cm2) |
0.39 (0.34–0.43) |
0.36 (0.31–0.41) |
0.04 |
0.40 (0.36–0.43) |
0.38 (0.32–0.42) |
0.33 (0.28–0.38) |
<0.01 |
0.38 (0.33–0.43) |
0.37 (0.31–0.41) |
0.34 (0.30–0.39) |
0.13 |
|
DXA-BMD change (%) |
-0.96 (-4.4 to 1.5) |
0.24 (-1.4 to 2.1) |
<0.01 |
-0.40 (-2.4 to 1.8) |
0.26 (-1.3 to 2.2) |
0.04 (-3.4 to 2.2) |
0.40 |
0.11 (-2.5 to 2.1) |
0.0 (-1.2 to 2.0) |
-0.12 (-4.1 to 2.2) |
0.75 |
|
DXR-BMD (g/cm2) |
0.57 (0.50–0.61) |
0.51 (0.44–0.56) |
<0.01 |
0.56 (0.50–0.61) |
0.53 (0.45–0.58) |
0.46 (0.38–0.52) |
<0.01 |
0.54 (0.49–0.59) |
0.49 (0.44–0.57) |
0.50 (0.40–0.53) |
<0.01 |
|
DXR-BMD change (%) |
-0.46 (-3.6 to 0.2) |
-0.93 (-2.8 to 0.3) |
0.76 |
-0.29 (-1.6 to 0.7) |
-1.13 (-3.2 to 0.1) |
-1.03 (-4.3 to 0.5) |
0.03 |
-0.80 (-2.6 to 0.1) |
-0.94 (-2.8 to 0.5) |
-0.81 (-3.7 to 0.5) |
0.90 |
|
DXR-MCI |
0.40 (0.37–0.49) |
0.37 (0.31–0.45) |
<0.01 |
0.41 (0.34–0.48) |
0.39 (0.33–0.46) |
0.32 (0.27–0.38) |
<0.01 |
0.40 (0.33–0.48) |
0.37 (0.31–0.43) |
0.33 (0.29–0.41) |
<0.01 |
|
DXR-MCI change (%) |
-0.89 (-5.5 to 0.0) |
-1.29 (-3.1 to -0.1) |
0.66 |
-0.76 (-1.8 to 0.3) |
-1.34 (-3.4 to -0.4) |
-1.13 (-5.2 to -0.2) |
0.06 |
-1.33 (-3.1 to -0.3) |
-1.20 (-3.2 to 0.3) |
-0.71 (-5.0 to 0.0) |
0.74 |
|
|
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|
Digital X-ray radiogrammetry (DXR) bone mineral density (BMD), DXR metacarpal cortical index (MCI) and dual-energy X-ray absorptiometry (DXA) BMD assessed for levels of disease duration, for disease activity (disease activity score including 28 joints (DAS28)) and for physical function (Modified Health Assessment Questionnaire (MHAQ)) in rheumatoid arthritis patients. Data presented as the medians (interquartile range). *P values between subgroups. |
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|
Hoff et al. Arthritis Research & Therapy 2007 9:R81 doi:10.1186/ar2280 |
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