Table 2

Comparison of the baseline and the change in hand bone mineral density

Disease duration

DAS28 at baseline

MHAQ at baseline


≤3 years

>3 years

P value*

<3.2

3.2–5.1

>5.1

P value

<1.50

1.50–1.99

≥2.0

P value


n

37

178

<0.01

55

103

44

<0.01

102

78

34

<0.01

Age (years)

55.4 (43–62)

58.0 (50–65)

0.10

53.5 (39–61)

55.8 (49–64)

62.2 (57–67)

<0.01

53.6 (41–64)

58.9 (52–64)

61.2 (54–67)

<0.01

DXA-BMD (g/cm2)

0.39 (0.34–0.43)

0.36 (0.31–0.41)

0.04

0.40 (0.36–0.43)

0.38 (0.32–0.42)

0.33 (0.28–0.38)

<0.01

0.38 (0.33–0.43)

0.37 (0.31–0.41)

0.34 (0.30–0.39)

0.13

DXA-BMD change (%)

-0.96 (-4.4 to 1.5)

0.24 (-1.4 to 2.1)

<0.01

-0.40 (-2.4 to 1.8)

0.26 (-1.3 to 2.2)

0.04 (-3.4 to 2.2)

0.40

0.11 (-2.5 to 2.1)

0.0 (-1.2 to 2.0)

-0.12 (-4.1 to 2.2)

0.75

DXR-BMD (g/cm2)

0.57 (0.50–0.61)

0.51 (0.44–0.56)

<0.01

0.56 (0.50–0.61)

0.53 (0.45–0.58)

0.46 (0.38–0.52)

<0.01

0.54 (0.49–0.59)

0.49 (0.44–0.57)

0.50 (0.40–0.53)

<0.01

DXR-BMD change (%)

-0.46 (-3.6 to 0.2)

-0.93 (-2.8 to 0.3)

0.76

-0.29 (-1.6 to 0.7)

-1.13 (-3.2 to 0.1)

-1.03 (-4.3 to 0.5)

0.03

-0.80 (-2.6 to 0.1)

-0.94 (-2.8 to 0.5)

-0.81 (-3.7 to 0.5)

0.90

DXR-MCI

0.40 (0.37–0.49)

0.37 (0.31–0.45)

<0.01

0.41 (0.34–0.48)

0.39 (0.33–0.46)

0.32 (0.27–0.38)

<0.01

0.40 (0.33–0.48)

0.37 (0.31–0.43)

0.33 (0.29–0.41)

<0.01

DXR-MCI change (%)

-0.89 (-5.5 to 0.0)

-1.29 (-3.1 to -0.1)

0.66

-0.76 (-1.8 to 0.3)

-1.34 (-3.4 to -0.4)

-1.13 (-5.2 to -0.2)

0.06

-1.33 (-3.1 to -0.3)

-1.20 (-3.2 to 0.3)

-0.71 (-5.0 to 0.0)

0.74


Digital X-ray radiogrammetry (DXR) bone mineral density (BMD), DXR metacarpal cortical index (MCI) and dual-energy X-ray absorptiometry (DXA) BMD assessed for levels of disease duration, for disease activity (disease activity score including 28 joints (DAS28)) and for physical function (Modified Health Assessment Questionnaire (MHAQ)) in rheumatoid arthritis patients. Data presented as the medians (interquartile range). *P values between subgroups.

Hoff et al. Arthritis Research & Therapy 2007 9:R81   doi:10.1186/ar2280

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