Prostaglandin PGE₂at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy

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Elena V Tchetina, John A Di Battista, David J Zukor, John Antoniou and A Robin Poole^*