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Relationship between vitamin C and vitamin E intake and knee structures |
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| Univariate analysis |
Multivariate analysis |
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| Regression coefficient (odds ratio (95% confidence interval)) |
P value |
Regression coefficient (odds ratio (95% confidence interval)) |
P value |
|
|
|
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| Vitamin C |
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| Cartilage volumea |
-41.9 (-173.2 to 89.4) |
0.53 |
-60.8 (-147.9 to 26.3) |
0.17 |
| Cartilage defectsb |
1.03 (0.81–1.31) |
0.82 |
1.02 (0.76–1.36) |
0.90 |
| Bone areac |
-9.3 (-65.1 to 46.5) |
0.74 |
-35.5 (-68.8 to -2.3) |
0.04 |
| Bone marrow lesionsd |
0.63 (0.40–0.99) |
0.05 |
0.50 (0.29–0.87) |
0.01 |
| Vitamin E |
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| Cartilage volume |
186.5 (58.4–314.5) |
0.004 |
57.3 (-37.8 to 152.4) |
0.24 |
| Cartilage defects |
0.96 (0.76–1.22) |
0.74 |
1.00 (0.72–1.33) |
0.89 |
| Bone area |
73.8 (19.3–128.2) |
0.01 |
27.0 (-9.6 to 63.6) |
0.15 |
| Bone marrow lesions |
1.10 (0.80–1.50) |
0.56 |
1.10 (0.73–1.66) |
0.66 |
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aChange in tibial cartilage volume (mm3) per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, body mass index, and tibial plateau bone area. bOdds ratio of tibiofemoral cartilage defects being present per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, body mass index, and tibial cartilage volume. cChange in tibial plateau bone area (mm2) per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, and body mass index. dOdds ratio of tibiofemoral bone marrow lesions being present per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, and body mass index. | ||||
Wang et al. Arthritis Research & Therapy 2007 9:R66 doi:10.1186/ar2225 |
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