Table 3 |
|||
|
Summary of effects of the root extracts* |
|||
|
Parameter |
Assay |
Change |
No. of mice per group |
|
|
|||
|
Leukocyte count, exudate |
Cell count |
-87% |
10 |
|
Neutrophil density, membrane |
Cell count |
-68% |
4 |
|
IL-6 protein, exudate |
ELISA |
-50% |
7 |
|
IL-6 mRNA, membrane |
qRT-PCR |
-100% |
4 + 4** |
|
TNF-α mRNA, membrane |
qRT-PCR |
-100% |
4 + 4** |
|
PGE2, exudate |
ELISA |
-69% |
7 |
|
PGD2, exudate |
ELISA |
+5.2-fold |
7 |
|
Ratio of PGD2:PGE2 |
ELISA |
+9.0-fold |
7 |
|
h-PGDS mRNA, membrane |
qRT-PCR |
+3.7-fold |
5 |
|
|
|||
|
* Compared with MSU-stimulated pouches from mice fed water. All percentage differences were significant at p < 0.05. **Duplicate experiments. ELISA, enzyme-linked immunosorbent assay; h-PGDS, hematopoietic prostaglandin D synthase; IL, interleukin; MSU, monosodium urate; PGD2, prostaglandin D2; PGE2, prostaglandin E2; qRT-PCR, relative quantitative reverse transcriptase polymerase chain reaction; TNF, tumor necrosis factor. |
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|
Jung et al. Arthritis Research & Therapy 2007 9:R64 doi:10.1186/ar2222 |
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