|
Comparison of PTPN22 1858 genotypes in rheumatoid arthritis patients stratified according to anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor with all controls |
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| CT + TT genotype, n (%) |
CC genotype, n (%) |
Minor allele frequency |
Cases versus all controlsa |
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|
|
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| χ2 |
P value |
Pc value |
Odds ratio |
95% confidence interval |
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|
|
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| Anti-CCP antibody-positive |
113 (35.5) |
205 (64.5) |
0.196 |
24.99 |
0.0000006 |
0.0000024 |
2.01 |
1.51–2.67 |
| Anti-CCP antibody-negative |
40 (26.7) |
110 (73.3) |
0.145 |
1.97 |
0.16046 |
0.64184 |
1.32 |
0.88–2.00 |
| Rheumatoid factor-positive |
96 (36.4) |
168 (63.6) |
0.199 |
24.49 |
0.0000007 |
0.0000028 |
2.08 |
1.53–2.82 |
| Rheumatoid factor-negative |
28 (27.5) |
74 (72.5) |
0.142 |
1.87 |
0.17164 |
0.68656 |
1.38 |
0.85–2.23 |
|
Pc, corrected P value. aControls presented in Table 2 | ||||||||
Kokkonen et al. Arthritis Research & Therapy 2007 9:R56 doi:10.1186/ar2214 |
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