|
Frequency distribution of the 1858 C/T polymorphism of PTPN22 in patients with early rheumatoid arthritis and matched controls |
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| Genotype |
Patients (n = 504) |
Controls (n = 970) |
χ2 |
P value |
Pc value |
Odds ratio |
95% confidence interval |
||
|
|
|||||||||
| n |
% |
n |
% |
||||||
|
|
|||||||||
| CC |
338 |
67.1 |
761 |
78.5 |
22.68 |
0.000002 |
0.00001 |
0.56 |
0.44–0.72 |
| CT |
151 |
30.0 |
196 |
20.2 |
17.53 |
0.000028 |
0.00014 |
1.69 |
1.31–2.18 |
| TT |
15 |
3.0 |
13 |
1.3 |
4.76 |
0.02907 |
0.14535 |
2.26 |
1.01–5.08 |
| CT + TT |
166 |
33.0 |
209 |
21.5 |
22.68 |
0.000002 |
0.00001 |
1.79 |
1.40–2.29 |
| T allele |
181 |
18.0 |
222 |
11.4 |
23.84 |
0.000001 |
0.000005 |
1.69 |
1.36–2.11 |
|
Pc, corrected P value. | |||||||||
Kokkonen et al. Arthritis Research & Therapy 2007 9:R56 doi:10.1186/ar2214 |
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