|
Linkage effects found in OMRF pedigrees using stratification |
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| Linkage region |
LOD |
Cohort ethnicity |
Stratification criteria |
Ref(s) |
|
|
||||
| 2q34* |
P = 0.00002† |
AA |
Nephritis |
[93,94] |
| 5p15 |
6.2 |
EA, AA, HIS |
Alleged rheumatoid arthritis |
[98,99] |
| 5q14 |
5.0 |
EA |
Autoimmune thyroid disease |
[100] |
| 11p13 |
3.7 |
AA |
Discoid lupus, thrombocytopenia |
[101,102] |
| 11q14 |
4.7 |
AA |
Hemolytic anemia, nucleolar ANA |
[102-104] |
| 17p12 |
4.0 |
EA |
Vitiligo |
[22,105] |
| 19p13.2 |
3.6 |
EA |
Anti-dsDNA |
[87,106] |
|
*This region is orthologous to that containing the mouse lupus susceptibility locus sle7 [107]. †The 2q34 region was analyzed using sib-pair methods; therefore, a P value is generated instead of a log of odds (LOD) score. AA, African-American; ANA, anti-nuclear antibody; EA, European-American; HIS, Hispanic; OMRF, Oklahoma Medical Research Foundation. | ||||
Sestak et al. Arthritis Research & Therapy 2007 9:210 doi:10.1186/ar2176 |
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