Table 1

Confirmed linkage effects in systemic lupus erythematosus
Linkage region	LOD score	Study center	Study design	Associated gene(s)	Mouse ortholog	Cohort ethnicity	Ref(s)

1q23	4.0	OMRF	Extended pedigrees	FCGR2A, FCGR3A	sle1, nba2 [54]	EA, AA	[6,7]
1q31-32	3.8	UU	Extended pedigrees		sle1c [84]	EU	[6,85]
1q41-43	3.3	UCLA USC	Extended pedigrees	PARP*		EA, HIS	[7,86]
2q37	4.2	UU	Extended pedigrees	PDCD-1		EU	[13,87]
4p16	3.8	OMRF	Extended pedigrees		sle6 [88]	EA	[89,90]
6p11-21	4.2	UMN	Sib-pairs	HLA-DR	sles1 [88,91]	EA, HIS, AA	[16]
10q22-23	P = 0.0002^†	OMRF UCLA	Extended pedigrees, sib-pairs			AA	[92-94]
12q24	3.3	OMRF	Extended pedigrees			HIS, EA	[95]
16q12-13	3.4	UMN OMRF	Sib-pairs, extended pedigrees			EA, AA, HIS	[96,97]

Although there was initial evidence that PARP* was the gene responsible for this linkage [17], subsequent studies have failed to confirm an association [18-21]. ^†The initial linkage at 10q22 was described using allele sharing statistics; therefore, a P value is generated instead of a log of odds (LOD) score. AA, African-Americanl EA, European-American; EU, European; HIS, Hispanic; OMRF, Oklahoma Medical Research Foundation; UCLA, University of California at Los Angeles; USC, University of Southern California; UU, Uppsala University (Sweden).
Sestak et al. Arthritis Research & Therapy 2007 9:210 doi:10.1186/ar2176