Editorial
Inflammatory cells and bone loss in rheumatoid arthritis
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Correspondence: David R Haynes david.haynes@adelaide.edu.au
Discipline of Pathology, School of Medical Sciences, University of Adelaide, North Terrace, SA 5005, Australia
Arthritis Research & Therapy 2007, 9:104 doi:10.1186/ar2213
Published: 22 June 2007Abstract
Pathogenic bone erosion is often associated with inflammation. The destructive bone erosion that is often seen in rheumatoid arthritis is probably due to the close proximity of inflamed tissues to bone. Over the past decade, major advances have been made in our understanding of the factors that are crucial in regulating osteoclast bone resorption. It is not surprising that these factors are expressed by inflammatory cells that are present in the rheumatoid joint. It now appears that we can add neutrophils to the list of inflammatory cells found in the inflamed rheumatoid joint that express factors that regulate bone erosion.