Table 1

Genotype frequencies of the interferon induced with helicase domain 1 A946T polymorphism

Genotype frequency


GG

AG

AA


Rheumatoid arthritis

Patients

126 (13.7%)

446 (48.5%)

348 (37.8%)

Controls

144 (15.5%)

450 (48.4%)

335 (36.1%)

Odds ratio (95% confidence interval)

0.8 (0.6–1.1)

0.9 (0.8–1.2)

P value

0.2

0.6

Rheumatoid factor

Positive

76 (13.1%)

281 (48.5%)

222 (38.3%)

Negative

40 (15.2%)

126 (47.9%)

97 (36.9%)

Odds ratio (95% confidence interval)

0.8 (0.5–1.3)

1.0 (0.7–1.4)

P value

0.4

0.9

Cyclic citrullinated peptide

Positive

87 (13.1%)

328 (49.2%)

251 (37.7%)

Negative

31 (15.1%)

99 (48.3%)

75 (36.6%)

Odds ratio (95% confidence interval)

0.8 (0.5–1.4)

1.0 (0.7–1.4)

P value

0.5

1.0

Larsen score

Median

36.0 (13.4%)

27.5 (48.3%)

27.0 (38.3%)

P value

0.2


We assumed a multiplicative inheritance model by performing logistic regression. The model with the largest log-likelihood ratio was chosen as the one that best represented the mode of inheritance of the data.

Marinou et al. Arthritis Research & Therapy 2007 9:R40   doi:10.1186/ar2179

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