Arthritis Research & Therapy

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Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes

Hassan Afif1, Mohamed Benderdour2, Leandra Mfuna-Endam1, Johanne Martel-Pelletier1, Jean-Pierre Pelletier1, Nicholas Duval3 and Hassan Fahmi1*

Author Affiliations

1 Osteoarthritis Research Unit, Centre Hospitalier de l'Université de Montréal (CHUM), Notre-Dame Hospital, Department of Medicine, University of Montreal, Montreal, 1560 Sherbrooke East, Pavillon J.A DeSève, Y-2628, Montreal, QC, H2L 4M1, Canada

2 Centre de Recherche, Sacré-Coeur Hospital, 5400 Boulevard Gouin Ouest, Montréal, QC, H4J 1C5, Canada

3 Centre de Convalescence, Pavillon de Charmilles, 1487 Boulevard des Laurentides, Montréal, QC, H7M 2Y3, Canada

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Arthritis Research & Therapy 2007, 9:R31 doi:10.1186/ar2151

Published: 26 March 2007

Additional files

Additional file 1:

A PDF file showing the expression of PPARα and PPARβ proteins in normal and OA cartilage.

Format: PDF Size: 628KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

A PowerPoint file showing the effect of IL-1 on PPARα and PPARβ protein expression in OA chondrocytes.

Format: PPT Size: 254KB Download file

This file can be viewed with: Microsoft PowerPoint Viewer

Open Data