Table 1

Clinical summary of the 10 patients studied and their response to treatment

Patient

Clinical presentation

Affected joints

Serum uric acid (normal range, 160–390 μmol/l)

Serum creatinine (normal range, 44–80 μmol/l)

Hypouricemic treatment

Effect of anakinra (hours)

Patient assessment of improvement in pain (%)


Case 1 (female, 72 years old)

Chronic tophaceous gout, renal stones

Fingers, toes

637

79

Uricase

36

70

Case 2 (male, 70 years old)

Chronic tophaceous gout

Ankle, toes

564

202

Allopurinol

24

90

Case 3 (male, 72 years old)

Acute gout

Knee, ankle, foot

482

121

Allopurinol

24

90

Case 4 (male, 51 years old)

Acute gout

Ankle, toe

396

84

Allopurinol

24

100

Case 5 (male, 40 years old)

Acute gout

Ankle, toe

322

113

Allopurinol

36

100

Case 6 (female, 72 years old)

Acute gout

Feet, toe

572

72

None

36

80

Case 7 (male, 76 years old)

Acute gout

Ankle, foot

338

79

None

36

100

Case 8 (male, 70 years old)

Acute gout

Wrist, elbow, hand

779

406

None

48

50

Case 9 (male, 53 years old)

Chronic tophaceous gout

Elbow, finger, foot, ankle

660

84

Allopurinol

48

50

Case 10 (male, 38 years old)

Acute gout

Wrist, finger

540

84

None

24

60


So et al. Arthritis Research & Therapy 2007 9:R28   doi:10.1186/ar2143

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