Inhibition of monosodium urate-induced peritoneal neutrophil influx by anti-IL-1 treatment. (a) BALB/C mice were injected intraperitoneally with 0.5 mg monosodium urate (MSU) crystals together with PBS or anti-IL-1RI mAb (200 μg) or anakinra (200 μg). (b) BALB/C mice were injected intraperitoneally with 0.5 mg MSU crystals together with PBS or anti-TNF mAb (200 μg) or anakinra (200 μg). Neutrophil influx in the peritoneum was quantified 6 hours later. Values are the mean ± standard error of the mean of five mice per group. An unpaired Student's t test was used to calculate the P value.
So et al. Arthritis Research & Therapy 2007 9:R28 doi:10.1186/ar2143