Table 2 |
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BMP signaling in synovitis |
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Ex vivo human biopsies |
Increased expression of BMP2 and BMP6 [9] |
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Decreased expression of BMP4 and BMP5 [41] |
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Presence of BMP receptor Ia positive cells in RA [38] |
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Animal model data |
Influx of BMP receptor Ia positive cells precedes onset of arthritis [39] |
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BMP, bone morphogenetic protein; RA, rheumatoid arthritis. |
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Lories and Luyten Arthritis Research & Therapy 2007 9:207 doi:10.1186/ar2135 |
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