Table 3 |
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|
Summary of the small-effect QTL candidate genes |
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|
Gene |
Chr. |
Position (Mb) |
Description |
Difference between DBA/1 and FVB/N strains |
Difference during CIA in DBA/1 strain |
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|
|
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|
Phase |
Fold changea |
Phase |
Fold changeb |
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|
|
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|
Steap4 |
5 |
7.9 |
STEAP family member 4 |
NC/PI/CA |
12.9/7.1/-5.9 |
CA |
-8.3 |
|
Add1 |
5 |
33.6 |
Adducin 1 (alpha) |
NC/PI |
5.1/3.3 |
CA |
-4.6 |
|
Wdr1 |
5 |
37.8 |
WD repeat domain 1 |
NC/PI/OA/CA |
4.9/3.5/2.4/-3.2 |
CA |
-7.1 |
|
Cd38 |
5 |
43.1 |
CD38 antigen |
NC/PI |
5.7/4.0 |
CA |
-3.6 |
|
Tgfbr3 |
5 |
106.2 |
Transforming growth factor, beta receptor III |
NC/PI/CA |
8.7/6.9/-3.2 |
CA |
-3.9 |
|
Oas1a |
5 |
120.1 |
2'-5' Oligoadenylate synthetase 1A |
NC |
-2.5 |
OA |
2.7 |
|
Baz1b |
5 |
134.1 |
Bromodomain adjacent to zinc finger domain, 1B |
NC/PI |
5.9/5.7 |
CA |
-6.7 |
|
Lfng |
5 |
139.5 |
Lunatic fringe gene |
NC/PI/OA |
8.8/4.6/2.5 |
CA |
-7.7 |
|
Gna12 |
5 |
139.7 |
Guanine nucleotide binding protein, alpha 12 |
NC/PI/OA |
4.1/3.7/3.3 |
CA |
-3.5 |
|
8430419L09Rik |
6 |
135.2 |
RIKEN cDNA 8430419L09 gene |
NC/PI/OA |
17.8/12.8/3.3 |
CA |
-4.2 |
|
Etnk1 |
6 |
143.2 |
Ethanolamine kinase 1 |
NC/PI/OA |
4.6/3.9/2.6 |
CA |
-5.6 |
|
Nnp1 |
10 |
78.05 |
Novel nuclear protein 1 |
NC |
3.0 |
CA |
-3.5 |
|
Kpnb1 |
11 |
97.2 |
Karyopherin (importin) beta 1 |
NC/PI/OA/CA |
12.1/7.3/3.2/-20 |
CA |
-50 |
|
Stat5a |
11 |
100.9 |
Signal transducer and activator of transcription 5A |
NC/PI |
5.3/3.0 |
CA |
-4.6 |
|
Pscd1 |
11 |
118.2 |
Pleckstrin homology, Sec7 and coiled-coil domains 1 |
NC/PI/OA/CA |
4.7/3.6/2.4/-4 |
CA |
-11 |
|
Mapk8ip3 |
17 |
23.07 |
Mitogen-activated protein kinase 8 interacting protein 3 |
NC/PI |
3.9/2.5 |
CA |
-3.1 |
|
Mapk14 |
17 |
26.8 |
Mitogen activated protein kinase 14 |
NC/PI/OA/CA |
9.1/4.7/3.1/-14 |
CA |
-33.3 |
|
A430107D22Rik |
17 |
30.5 |
RIKEN cDNA A430107D22 gene |
NC |
3.7 |
CA |
-5 |
|
Hspa1a |
17 |
33 |
Heat shock protein 1A |
PI/CA |
-3.8/-4.6 |
PI/OA |
3.8/5.4 |
|
H2-Q10 |
17 |
33.5 |
Histocompatibility 2, Q region locus 10 |
NC/PI/OA/CA |
3.3/4.2/2.5/5.3 |
CA |
-3 |
|
Gabbr1 |
17 |
35.1 |
Gamma-aminobutyric acid receptor 1 |
NC/PI |
4.9/2.5 |
CA |
-6.3 |
|
|
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|
aFold change calculated by comparing DBA/1 with FVB/N. bFold change calculated by comparing post-immunisation (PI), onset of arthritis (OA) and chronic arthritis (CA) with naive control (NC), respectively. Chr., chromosome; CIA, collagen-induced arthritis. |
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|
Yu et al. Arthritis Research & Therapy 2007 9:R3 doi:10.1186/ar2108 |
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