Research article
Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis
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* Corresponding author: Saleh M Ibrahim saleh.ibrahim@med.uni-rostock.de
1 Immunogenetics Group, University of Rostock, Schillingallee, 18055 Rostock, Germany
2 Institute for Immunology, University of Rostock, Schillingallee, 18055 Rostock, Germany
Arthritis Research & Therapy 2007, 9:R3 doi:10.1186/ar2108
Published: 23 January 2007Additional files
Additional file 1:
Summary information on the 509 genes differentially expressed between DBA/1 and FVB/N strains. Comparison was performed between two strains at four stages of CIA, NA, PI, OA and CA. Three criteria were applied for selecting the differentially expressed genes: the lower 90% confidence bound of fold change between the group means exceeded twofold; the absolute difference between the two groups exceeded 100; the P value threshold of the unpaired t-test was 0.05
Format: XLS Size: 488KB Download file
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Additional file 2:
Summary information on the 311 genes differentially expressed in joints in the DBA/1 strain during CIA. Pairwise comparisons were performed by comparing PI, OA and CA with NA. Three criteria were applied for selecting the differentially expressed genes: the lower 90% confidence bound of fold change between the group means exceeded twofold; the absolute difference between the two groups exceeded 100; the P value threshold of the unpaired t-test was 0.05
Format: XLS Size: 263KB Download file
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Additional file 3:
Summary information on the 117 genes that were strain-specific differentially expressed and were dysregulated in the DBA/1 strain during CIA. The physical positions of the genes were retrieved from Ensembl [30]
Format: XLS Size: 30KB Download file
This file can be viewed with: Microsoft Excel Viewer