Volumetric bone mineral density analysis over the time course. Micro-CT scans were used to assess vBMD over the 20-week time course. vBMD was compared between NM and FM groups in (a,b) the MTP and (c,d) MFC of sham, and contralateral and ipsilateral treatments. Mean vBMD values ± standard error are shown. No significant effect of FM on vBMD was observed in sham, contralateral, or ipsilateral treatments (compared with NM counterparts). Contralateral vBMD means were not significantly different from sham vBMD means at any time point (statistics not indicated). Statistical analysis is done for each individual time point to indicate significantly different means among the four contralateral and ipsilateral treatments. Only at the time points where significantly different means were identified are similar means encircled, whereas significantly different means are indicated by different circles labeled a or b (P < 0.05; n = 4). CT, computed tomography; FM, forced mobilization; MFC, medial femoral compartment; MTP, medial tibial plateau; NM, nonmobilized; vBMD, volumetric bone mineral density.
Appleton et al. Arthritis Research & Therapy 2007 9:R13 doi:10.1186/ar2120