Table 1 |
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|
Surface antigens commonly identified during isolation of mesenchymal stem cells (MSCs) |
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Number of populations reported with specified antigen levelsb |
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|
|
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|
Human MSCsc |
Murine MSCsc |
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|
|
|
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|
Marker type |
Surface antigena |
+ |
+/- |
- |
+ |
+/- |
- |
References |
|
|
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|
Positive |
Stro-1 |
7 |
1 |
2 |
0 |
0 |
0 |
4–7,66,82–84 |
|
CD13 |
5 |
0 |
0 |
1 |
0 |
1 |
2,12,84–87,89–90 |
|
|
CD29 |
5 |
0 |
0 |
11 |
0 |
0 |
2,12,63,84–87,90 |
|
|
CD44 |
11 |
0 |
1 |
10 |
1 |
0 |
2,63,82,84–87,90–91 |
|
|
CD73 |
5 |
0 |
0 |
0 |
0 |
0 |
2,10,83–85 |
|
|
CD105 |
7 |
0 |
0 |
1 |
0 |
0 |
2,10,12,83–87 |
|
|
CD106 |
4 |
0 |
2 |
4 |
1 |
0 |
2,5,83–84,86–89 |
|
|
Negative |
CD11b |
0 |
0 |
3 |
0 |
1 |
5 |
2,82,86–88,90 |
|
CD31 |
0 |
3 |
10 |
0 |
0 |
6 |
2,82,84–91 |
|
|
CD34 |
1 |
1 |
10 |
5 |
6 |
3 |
2,12,63,82,84–89,91 |
|
|
CD45 |
0 |
0 |
11 |
0 |
0 |
6 |
2,82,84–91 |
|
|
CD117 |
0 |
2 |
3 |
1 |
1 |
13 |
2,63,82,87–90 |
|
|
Variable |
Sca-1 |
0 |
0 |
0 |
6 |
5 |
4 |
63,87–88,90 |
|
CD10 |
6 |
0 |
5 |
0 |
1 |
0 |
82,85–87,89 |
|
|
CD90 |
11 |
1 |
1 |
2 |
4 |
10 |
2,12,63,82,84–85,87–91 |
|
|
Flk-1 |
2 |
1 |
1 |
0 |
0 |
5 |
82,88–89 |
|
|
|
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|
aAntigen chosen if tested in at least 4 MSC populations from the 19 papers reviewed; bnumber of MSC populations (isolated from various tissues from human or mouse) reported in these studies to be mostly positive (+), somewhat positive (+/-), or negative (-); cMSCs isolated primarily from bone marrow but also from fat, skin, thymus, kidney, muscle, liver, lung, and placenta. |
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|
Kolf et al. Arthritis Research & Therapy 2007 9:204 doi:10.1186/ar2116 |
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