This article is part of a series on
Mesenchymal stromal cells, edited by
Steffen Gay.
 ReviewMesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiationCatherine M Kolf*  , Elizabeth Cho* and Rocky S Tuan  Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 50 South Drive, Bethesda, MD 20892, USA  author email corresponding author email* Contributed equally
Arthritis Research & Therapy 2007,
9:204doi:10.1186/ar2116
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| Published: |
19 February 2007 |
Abstract
Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells. | 
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