Table 1

Variables in three recent studies of apoptotic cells induced by photoprovocation

Reefman et al. [1]

Kuhn et al. [11]

Jannsens et al. [12]

Patients

SLE

DLE, SCLE, TLE

DLE, SCLE, SLE

Photosensitive

6/15

All

All

Treatment

Steroids, azathioprine

No steroids

3/22 steroids

Controls

Healthy

SLE, healthy

Healthy

UV

UVB, 2MEDs

UVA or UVB, 1.5 MED

UVB, 6 MEDs

Site

Buttock

Upper back

Buttock

Frequency

Once

Three times

Once

Apoptosis detection

Sunburn cells, casp3

ISNT, TUNEL, casp3

Casp3

Time analyzed (days)

3, 10

1, 3 and up to 28

1, 2, 3

Casp3, activated caspase 3; DLE, discoid lupus erythematosus; ISNT, in situ nick translation; MED, minimal erythemal dose; SCLE, subacute cutaneous lupus erythematosus; SLE, systemic lupus erythematosus; TLE, tumid lupus erythematosus; TUNEL, in situ nick end labeling.

Kuechle and Elkon Arthritis Research & Therapy 2007 9:101   doi:10.1186/ar2100