Table 4 |
||||
|
Relative signal values of articular cartilage extracellular-matrix-related genes significantly affected by IL-1 and/or glucosamine |
||||
| Gene |
Treatment group |
|||
| No glucosamine, no IL-1 |
Glucosamine, no IL-1 |
IL-1, no glucosamine |
Glucosamine with IL-1 |
|
|
|
||||
| A disintegrin and metalloproteinase domain 15 |
142.9 |
121.3 |
64.9 |
98.3 |
| A disintegrin and metalloproteinase domain 17 |
434.6 |
533.1 |
897.4 |
616.6 |
| ADAMTS-1 |
457.0 |
202.1 |
996.0 |
359.7 |
| ADAMTS-4 |
79.2 |
149.8 |
76.0 |
149.4 |
| Aggrecan-1 |
162.6 |
154.7 |
47.1 |
117.3 |
| Biglycan |
80.9 |
26.1 |
126.8 |
19.2 |
| Cartilage link protein |
662.1 |
284.3 |
75.9 |
166.7 |
| Chondroitin sulfate proteoglycan 2 (Versican) |
135.3 |
45.3 |
418.1 |
60.0 |
| Collagen type II alpha 1, chain precursor |
106.4 |
42.0 |
3.8 |
20.6 |
| Collagen type III alpha 1 |
2710.2 |
2720.0 |
1320.4 |
2242.6 |
| Collagen type VIII alpha 1 |
622.6 |
362.5 |
857.9 |
493.8 |
| Collagen type XI alpha 1 |
2510.6 |
2090.9 |
1471.5 |
1830.9 |
| Laminin α-4 chain precursor |
238.3 |
510.2 |
158.6 |
410.8 |
| Matrix metalloproteinase 2 |
1014.0 |
1388.4 |
1825.7 |
1886.2 |
| Matrix metalloproteinase 3 |
894.7 |
1966.4 |
5787.4 |
4223.6 |
| Matrix metalloproteinase 9 |
- |
11.1 |
2194.0 |
36.5 |
| Matrix metalloproteinase 10 |
- |
7.8 |
271.2 |
39.6 |
| Matrix metalloproteinase 12 |
4.9 |
13.4 |
1132.0 |
84.9 |
| Matrix metalloproteinase 13 |
268.3 |
2126.9 |
4497.4 |
3871.2 |
| Syndecan 2 |
1515.8 |
1292.9 |
656.8 |
963.4 |
| Syndecan 4 |
927.7 |
796.8 |
2049.2 |
1327.5 |
| Thrombospondin 4 precursor |
2535.4 |
2217.7 |
1224.9 |
1662.6 |
| TIMP-1 |
1786.8 |
1857.2 |
3049.8 |
2311.4 |
| TIMP-2 |
995.9 |
937.0 |
726.9 |
923.1 |
| TIMP-3 |
1317.1 |
1983.9 |
1105.3 |
1859.0 |
|
|
||||
|
Gouze et al. Arthritis Research & Therapy 2006 8:R173 doi:10.1186/ar2082 |
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