Table 1 |
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List of genes upregulated in rheumatoid arthritis/osteoarthritis microarray analysis (HI380) |
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Genes upregulated in RA fibroblast-like synoviocytesa |
Functions |
RA/OA FLS ratiob |
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CD1A antigen, α polypeptide |
T cell activation |
2.6 |
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CD3D antigen, δ polypeptide (TiT3 complex) |
T cell activation |
3.7 |
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MLN51 gene |
Highly expressed in immature DCs |
6.8 |
|
CD6 antigen |
T cell activation |
2.5 |
|
CD21 antigen |
B cell activation |
2.1 |
|
CD24 antigen (small cell lung carcinoma cluster 4 antigen) |
Unknown for human CD24 |
4.3 |
|
CD26 antigen |
T cell activation |
4.1 |
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CD32 antigen (Fcγ receptor II) |
Formation of immune complexes |
2.2 |
|
CD33 antigen (gp67) |
Inhibition of myeloid cell proliferation |
3.8 |
|
CD36 antigen (collagen type I receptor, thrombospondin receptor) |
Recognition and phagocytosis of apoptotic cells |
2.5 |
|
CD42b antigen |
Adhesion or migration |
4.5 |
|
CD79A antigen (immunoglobulin-associated α) |
B cell activation |
2.4 |
|
CD171 antigen |
T cell activation |
3.6 |
|
CD206 antigen (macrophage mannose receptor) |
Apoptosis or endocytosis |
2.8 |
|
B cell linker protein (SLP65: BLNK) |
B cell activation |
4.0 |
|
Ig superfamily protein (Z39IG) |
Formation of immune complexes |
4.2 |
|
T cell transcription factor 4 (TCF-4) |
Enhancement of the release of extracellular matrix proteins |
2.1 |
|
IL-1 receptor type I |
T cell activation |
2.4 |
|
IL-7 receptor |
T and B cell activation |
2.5 |
|
IL-8 |
Migration |
3.0 |
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IL-9 |
T and mast cell activation |
2.7 |
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IL-17 |
T cell activation |
4.6 |
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Colony-stimulating factor 2 receptor, β, low-affinity (granulocyte – macrophage); CSF-2RB |
Cell cycle regulation |
2.3 |
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Colony-stimulating factor 3 receptor (granulocyte) |
Cell cycle regulation |
2.9 |
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Methyl-CpG-binding domain protein 1 (MBD1) |
Cell cycle regulation |
2.2 |
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DCs, dendritic cells; FLS, fibroblast-like synoviocyte; OA, osteoarthritis; RA, rheumatoid arthritis. aRA FLS 2–14 was used for this experiment. Values were obtained from one (OA 2–43) of three OA FLSs. bThis result was based on single experiments performed in triplicates, being similar to the cases performed with additional FLSs. |
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Jang et al. Arthritis Research & Therapy 2006 8:R170 doi:10.1186/ar2079 |
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