Table 3 |
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|
Change in gene expression, mean 2-ΔΔCT values, significance and power of comparisons between normal and OA canine articular cartilage |
||||||
|
Gene |
Number of samples in which expression was detected |
2-ΔΔCT normal |
2-ΔΔCT OA |
Fold change in expression (diseased versus normal) |
Mann-Whitney U test p value |
Power |
|
|
||||||
|
TIMP4 |
27 |
0.109 |
0.043 |
-0.608 |
0.0094 |
0.859 |
|
TIMP2 |
28 |
3.959 |
1.664 |
-0.580 |
0.0020 |
0.844 |
|
ADAMTS5 |
16 |
0.031 |
0.019 |
-0.551 |
0.8478 |
0.175 |
|
SDHA |
28 |
0.323 |
0.234 |
-0.275 |
0.0476 |
0.722 |
|
VIM |
28 |
32.742 |
28.909 |
-0.117 |
0.5493 |
0.195 |
|
TBP |
28 |
0.106 |
0.106 |
0.001 |
0.8178 |
0.051 |
|
DCN |
28 |
73.034 |
74.253 |
0.017 |
0.5190 |
0.059 |
|
GAPDH |
28 |
1.548 |
1.648 |
0.064 |
0.9633 |
0.105 |
|
RPL13A |
28 |
7.048 |
7.722 |
0.096 |
0.3814 |
0.275 |
|
CTSB |
26 |
0.280 |
0.476 |
0.698 |
0.0060 |
0.886 |
|
AGC |
28 |
0.082 |
0.155 |
0.887 |
0.1670 |
0.778 |
|
TNC |
28 |
2.700 |
5.205 |
0.927 |
0.0099 |
0.886 |
|
BGN |
28 |
15.511 |
30.984 |
0.998 |
0.0043 |
0.976 |
|
CTSD |
28 |
0.148 |
0.295 |
0.999 |
0.0066 |
0.944 |
|
COL9A3 |
27 |
0.231 |
0.546 |
1.365 |
0.0304 |
0.633 |
|
TIMP1 |
28 |
0.551 |
1.468 |
1.663 |
0.0008 |
0.853 |
|
LUM |
28 |
1.635 |
4.476 |
1.738 |
0.0015 |
0.991 |
|
CSPG2 |
27 |
0.079 |
0.279 |
2.530 |
0.0005 |
0.981 |
|
COL5A1 |
28 |
0.615 |
2.188 |
2.555 |
0.0069 |
0.887 |
|
COL3A1 |
26 |
10.573 |
37.867 |
2.581 |
0.0011 |
0.982 |
|
COL1A2 |
28 |
0.805 |
6.941 |
7.621 |
0.0043 |
0.737 |
|
MMP13 |
26 |
0.014 |
0.161 |
10.322 |
0.0010 |
0.857 |
|
COL2A1 |
27 |
1.412 |
23.583 |
15.705 |
0.0001 |
0.779 |
|
|
||||||
|
ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif, 5; AGC, aggrecan; BGN, biglycan; COL1A2, type I collagen, alpha two chain; COL2A1, type II collagen alpha 1 chain; COL3A1, type III collagen alpha 1 chain; COL5A1, type V collagen alpha 1 chain; COL9A3, type IX collagen alpha 3 chain; CSPG2, chondroitin sulphate proteoglycan 2; CTSB, cathepsin B; CTSD, cathepsin D; DCN, decorin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; LUM, lumican; MMP13, matrix metalloproteinase 13; OA, osteoarthritis; RPL13A, ribosomal protein L13a; SDHA, succinate dehydrogenase complex, subunit A; TBP, TATA box binding protein; TIMP1, tissue inhibitor of metalloproteinase 1; TIMP2, tissue inhibitor of metalloproteinase 2; TIMP4, tissue inhibitor of metalloproteinase 4; TNC, Tenascin C; VIM, vimentin. |
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|
Clements et al. Arthritis Research & Therapy 2006 8:R158 doi:10.1186/ar2053 |
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