Figure 5.

Apoptosis induced by PUMA in the presence of mutant p53. Human fibroblast-like synoviocytes (FLS) were transfected with dominant-negative p53 cDNA R213* or empty vector (Emp) followed by transfection with PUMA cDNA. Apoptosis was induced in FLS despite expression of the dominant-negative protein. *p < 0.05, n = 3.