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Review

Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia

David A Williams12 and Richard H Gracely13*

Author Affiliations

1 Chronic Pain and Fatigue Research Center, Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, University of Michigan, Ann Arbor, MI, USA

2 Department of Psychiatry, University of Michigan Health System, University of Michigan, Ann Arbor, MI, USA

3 Department of Neurology, University of Michigan Health System, University of Michigan and Ann Arbor VAMC, Ann Arbor, MI, USA

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Arthritis Research & Therapy 2006, 8:224  doi:10.1186/ar2094

Published: 17 January 2007

Abstract

Techniques in neuroimaging such as functional magnetic resonance imaging (fMRI) have helped to provide insights into the role of supraspinal mechanisms in pain perception. This review focuses on studies that have applied fMRI in an attempt to gain a better understanding of the mechanisms involved in the processing of pain associated with fibromyalgia. This article provides an overview of the nociceptive system as it functions normally, reviews functional brain imaging methods, and integrates the existing literature utilizing fMRI to study central pain mechanisms in fibromyalgia.