Table 2

The relative AMI risk associated with the use individual NSAIDs compared with remote or no use.

Drug [ref.]

Relative AMI risk

95% CI

Test for heterogeneity

Test for inconsistency

χ²

P value

I²

Diclofenac

1.41

1.20–1.65

9.79

0.08

48.9%

[27]

1.38

1.08–1.77

[16]

1.68

1.14–2.48

[19]

1.18

0.99–1.40

[6]

1.55

1.39–1.72

[18]

1.23

1.00–1.51

Ibuprofen

1.11

1.04–1.18

8.26

0.41

3.2%

[25]

1.15

1.03–1.29

[24]

1.01

0.77–1.33

[27]

1.17

0.87–1.58

[28]

1.02

0.88–1.18

[16]

0.74

0.35–1.56

[19]

1.06

0.87–1.29

[20]

1.06

0.96–1.17

[6]

1.24

1.11–1.39

[18]

1.16

0.92–1.46

Naproxen

0.99

0.88–1.12

23.91

0.01

54%

[25]

0.95

0.82–1.10

[24]

0.93

0.74–1.17

[27]

0.68

0.41–1.12

[28]

0.84

0.72–0.98

[16]

0.57

0.31–1.05

[23]

1.00

0.59–1.68

[19]

0.89

0.64–1.24

[20]

1.14

1.00–1.30

[6]

1.27

1.01–1.60

[21]

1.50

0.99–2.28

[22]

1.17

0.75–1.83

[18]

0.96

0.66–1.39

AMI, acute myocardial infarction; CI, confidence interval; NSAID, nonsteroidal anti-inflammatory drug.

Singh et al. Arthritis Research & Therapy 2006 8:R153   doi:10.1186/ar2047