Figure 4.

Correlation between age and epinephrine (EPI) effects in patients with rheumatoid arthritis (RA) and healthy subjects. The age of the subjects was plotted against concentrations of the relative interferon (IFN)-γ in (a) healthy donors (HDs) and (b) patients with RA and of interleukin (IL)-10 in (c) HDs and (d) patients with RA after co-incubation of activated T cells with 10^-5 M EPI for 48 hours. The baseline values of each HD and patient with RA were defined as 100%. (Concentrations are presented in Figure 1 legend.) The cytokine concentrations upon co-incubation with 10^-5 M EPI are given as percentage of baseline values. p, the p value; r, the respective correlation coefficient.