Table 3 |
||||
|
Circulating leptin levels in patients with immune-mediated inflammatory diseases |
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|
Diseases |
Leptin levels: patients versus healthy controls |
Correlation of leptin levels with disease activity |
Comments |
References |
|
|
||||
|
RA |
Elevated |
No correlation with CRP |
No data on BMI |
[91] |
|
RA |
Elevated |
Correlation with CRP |
Different gender distribution in the groups |
[92] |
|
RA |
Similar |
No correlation |
Correlated with BMI and percentage of body fat |
[94] |
|
RA |
Similar |
No correlation |
Correlated with BMI |
[95] |
|
RA |
Similar |
Negative correlation with CRP |
No effect of short course anti-TNF-α therapy |
[97] |
|
and IL-6 |
on leptin levels |
|||
|
RA |
Reduced |
No correlation |
No correlation with BMI, CRP or total fat mass |
[96] |
|
SLE |
Elevated |
No correlation |
Correlated with BMI |
[102] |
|
Systemic sclerosis |
Reduced |
No correlation |
Correlated with BMI |
[103] |
|
Behçet's disease |
Elevated |
Positive correlation |
Gender ratio, age and BMI similar in patient and control groups |
[104] |
|
Multiple sclerosis |
Similar |
Positive correlation |
Leptin levels increased before exacerbation and decreased after treatment with IFN-β |
[100] |
|
Multiple sclerosis |
Similar |
No correlation |
Leptin levels increased in IFN-β treated patients during active disease and remission |
[101] |
|
|
||||
|
BMI, body mass index; CRP, C-reactive protein; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; TNF, tumor necrosis factor. |
||||
|
Bernotiene et al. Arthritis Research & Therapy 2006 8:217 doi:10.1186/ar2004 |
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