Table 2 |
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|
Heritability estimates for the prevalence and severity of bone marrow lesions |
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| Parameter |
Step 1 |
Step 2 |
Step 3 |
Step 4 |
||||
| h2 |
p |
h2 |
p |
h2 |
p |
h2 |
p |
|
|
|
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| Lateral compartment |
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| Severity of BML |
60 ± 26 |
0.01 |
53 ± 28 |
0.03 |
45 ± 28 |
0.06 |
45 ± 28 |
0.06 |
| Prevalent BML |
100 |
<0.01 |
100 |
0.02 |
99 |
0.04 |
99 |
0.05 |
| Medial compartment |
||||||||
| Severity of BML |
20 ± 25 |
0.21 |
65 ± 32 |
0.03 |
46 ± 31 |
0.07 |
56 ± 31 |
0.04 |
| Prevalent BML |
100 |
0.01 |
100 |
<0.01 |
99 |
0.02 |
99 |
0.01 |
|
|
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|
Where errors are shown, values are means ± SD. BML, bone marrow lesions; h2, heritability estimate. In step 1, h2 was estimated after adjustment for age, sex, height and weight; in step 2, further adjustment was made for muscle strength, knee pain and knee alignment; in step 3, further adjustment was made for chondral defects; in step 4, further adjustment was made for radiographic osteoarthritis. |
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|
Zhai et al. Arthritis Research & Therapy 2006 8:R137 doi:10.1186/ar2027 |
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