Figure 8.

Compression increases NAD+-dependent 15 hydroxy prostaglandin dehydrogenase (15-PGDH) transcriptional expression in mouse costal cartilage explants. The rate of 15-PGDH mRNA expression in response to a compressive stress (C) at 2 hours and 4 hours was analyzed by real-time quantitative RT-PCR. Increased 15-PGDH mRNA expression was observed after 4 hours of a compressive stress. Values are the mean ± SEM of 3 independent experiment with n = 1/group/experiment. *p < 0.05 versus control (NC).