Table 3

Association between SE alleles and anti-CCP status

RF status

Number of SE alleles

Proportion anti-CCP positive

OR (95% CI)

P


All

2

214/241

4.94 (2.94–8.22)

<0.001

1

307/373

2.90 (1.89–4.43)

0

98/159

1

RF positive

2

162/170

4.15 (1.79–9.58)

<0.01

1

236/253

2.85 (1.41–5.77)

0

78/94

1

RF negative

2

52/71

6.16 (3.00–12.6)

<0.001

1

71/120

3.26 (1.74–6.11)

0

20/65

1


Absolute numbers of anti-CCP-positive patients in each subgroup are given. OR with 95% CI are shown for anti-CCP positivity associated with carriage of two or one SE allele versus no SE alleles for RF positive, RF negative and combined subgroups. P values are for χ2 tests with two degrees of freedom comparing the proportion of anti-CCP positive patients in subgroups carrying two, one, or no SE alleles. anti-CCP, anti-cyclic citrullinated peptide antibody; CI, confidence interval; NS, not significant; OR, odds ratio; RF, rheumatoid factor; SEM, standard error of the mean.

Mewar et al. Arthritis Research & Therapy 2006 8:R128   doi:10.1186/ar2017

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