Table 3 |
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|
Class distribution of differentially expressed genes with a log odds ratio >1 |
||
|
Gene symbol |
Gene title |
M |
|
|
||
|
Angiogenesis |
||
|
MT1A |
↑ Metallothionein 1A |
3.25 |
|
PLAT |
↑ Plasminogen activator, tissue |
2.23 |
|
ANGPTL4 |
↑ Angiopoietin-like 4 |
1.97 |
|
CTGF |
↑ Connective tissue growth factor |
1.80 |
|
ENO1 |
↑ Enolase 1 |
1.67 |
|
PTX3 |
↑ Pentaxin-related gene, rapidly induced by IL-1 beta |
1.66 |
|
VCL |
↑ Vinculin |
1.65 |
|
LAMR1 |
↑ Laminin receptor 1 |
1.63 |
|
PFN1 |
↑ Profilin 1 |
1.54 |
|
MT2A |
↑ Metallothionein 2A |
1.50 |
|
SPOCK |
↑ Sparc/osteonectin (testican) |
1.46 |
|
MT1E |
↑ Metallothionein 1E |
1.43 |
|
CCND1 |
↑ Cyclin D1 |
1.40 |
|
CFL1 |
↑ Cofilin 1 |
1.31 |
|
CAPN2 |
↑ Calpain 2, large subunit |
1.28 |
|
MIF |
↑ Macrophage migration inhibitory factor |
1.24 |
|
WDR1 |
↑ WD repeat domain 1 |
1.21 |
|
IL8 |
↑ IL8 |
1.18 |
|
CLSTN1 |
↑ Calsyntenin 1 |
1.07 |
|
ADAM15 |
↑ A disintegrin and metalloproteinase domain 15 |
1.06 |
|
EFEMP1 |
↑ EGF-containing fibulin-like extracellular matrix protein 1 |
1.03 |
|
KLK9 |
↓ Kallikrein 9 |
-1.23 |
|
PLXNB1 |
↓ Plexin B1 |
-1.19 |
|
KLK12 |
↓ Kallikrein 12 |
-1.08 |
|
KLK11 |
↓ Kallikrein 11 |
-1.08 |
|
DSG2 |
↓ Desmoglein 2 |
-1.04 |
|
Apoptosis |
||
|
TNFRSF6B |
↑ Tumor necrosis factor receptor superfamily, member 6b, decoy |
2.20 |
|
PRG1 |
↑ Proteoglycan 1, secretory granule |
1.32 |
|
CFL1 |
↑ Cofilin 1 |
1.31 |
|
CAPN2 |
↑ Calpain 2, (m/II) large subunit |
1.28 |
|
SGK |
↑ Serum/glucocorticoid regulated kinase |
1.27 |
|
MIF |
↑ Macrophage migration inhibitory factor |
1.24 |
|
PEA15 |
↑ Phosphoprotein enriched in astrocytes 15 |
1.23 |
|
MTCH1 |
↑ Mitochondrial carrier homolog 1 |
1.08 |
|
Haemostasis, inflammation and immunity |
||
|
PLAT |
↑ Plasminogen activator, tissue |
2.23 |
|
ENO1 |
↑ Enolase 1 |
1.67 |
|
PTX3 |
↑ Pentaxin-related gene |
1.66 |
|
IFITM2 |
↑ Interferon induced transmembrane protein 2 |
1.27 |
|
B2M |
↑ Beta-2-microglobulin |
1.26 |
|
ILF2 |
↑ Interleukin enhancer binding factor 2 |
1.15 |
|
LBP |
↓ Lipopolysaccharide binding protein |
-1.77 |
|
PTGDS |
↓ Prostaglandin D2 synthase 21 kDa |
-1.14 |
|
AZU1 |
↓ Azurocidin 1 |
-1.02 |
|
Stress/ubiquitination |
||
|
ATOX1 |
↑ ATX1 antioxidant protein 1 homolog |
1.51 |
|
UCHL1 |
↑ Ubiquitin carboxy-terminal esterase L1 |
1.33 |
|
ANAPC11 |
↑ Anaphase promoting complex subunit 11 homolog |
1.28 |
|
FTL |
↑ Ferritin, light polypeptide |
1.25 |
|
PMP22 |
↑ Peripheral myelin protein 22 |
1.19 |
|
SLC38A2 |
↑ Solute carrier family 38, member 2 |
1.14 |
|
PSMC1 |
↑ Proteasome (prosome, macropain) 26S subunit, ATPase, 1 |
1.12 |
|
FKBP4 |
↑ FK506 binding protein 4 |
1.12 |
|
PSMD13 |
↑ Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 |
1.03 |
|
PRDX1 |
↑ Peroxiredoxin 1. |
1.02 |
|
ANAPC10 |
↓ Anaphase promoting complex subunit 10 |
-1.22 |
|
Transduction |
||
|
GJA1 |
↑ Gap junction protein, alpha 1, 43 kDa (connexin 43) |
1.39 |
|
HPCAL1 |
↑ Hippocalcin-like 1 |
1.36 |
|
CFL1 |
↑ Cofilin 1 |
1.31 |
|
RAC2 |
↑ Ras-related C3 botulinum toxin substrate 2 |
1.30 |
|
SGK |
↑ Serum/glucocorticoid regulated kinase |
1.27 |
|
IL6ST |
↑ Interleukin 6 signal transducer (gp130, oncostatin M receptor) |
1.15 |
|
ARHGDIB |
↑ Rho GDP dissociation inhibitor beta |
1.10 |
|
GNG10 |
↑ Guanine nucleotide binding protein, gamma 10 |
1.05 |
|
PRDX4 |
↑ Peroxiredoxin 4 |
1.05 |
|
RHOA |
↑ Ras homolog gene family, member A |
1.02 |
|
PLXNB1 |
↓ Plexin B1 |
-1.19 |
|
MAP4K1 |
↓ Mitogen-activated protein kinase/kinase/kinase/kinase 1 |
-1.05 |
|
DNA/RNA organization |
||
|
SBDS/CGI97 |
↑ Shwachman-Bodian-Diamond syndrome |
2.14 |
|
ENO1 |
↑ Enolase 1 |
1.67 |
|
H3F3B |
↑ H3 histone, family 3B |
1.37 |
|
TRUB2 |
↓ TruB pseudouridine synthase homolog 2 |
-1.23 |
|
AVPI1 |
↓ Arginine vasopressin-induced 1 |
-1.12 |
|
C1orf34 |
↓ Chromosome 1 open reading frame 34 |
-1.05 |
|
Transcription |
||
|
BTF3L3 |
↑ Basic transcription factor 3, like 3 |
1.21 |
|
ILF2 |
↑ Interleukin enhancer binding factor 2 |
1.15 |
|
GATA6 |
↓ GATA binding protein 6 |
-2.19 |
|
SOX9 |
↓ SRY (sex determining region Y)-box 9 |
-1.99 |
|
RUNX2 |
↓ Runt-related transcription factor 2 |
-1.16 |
|
NFAT5 |
↓ Nuclear factor of activated T-cells 5 |
-1.14 |
|
SOX5P |
↓ SRY (sex determining region Y)-box 5 |
-1.12 |
|
FOXA2 |
↓ Forkhead box A2 |
-1.10 |
|
|
||
|
All genes with a log odds ratio >0 were considered significantly down-regulated (M < 0) or up-regulated (M > 0). The table reports only genes with M > 1 and M < 1. Upward and downward arrows indicate up- and down-regulation, respectively. |
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|
Giusti et al. Arthritis Research & Therapy 2006 8:R115 doi:10.1186/ar2002 |
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