Additional File 1.

(a) A PDF file showing the 150 most expressed genes in MVECs, independent of their tissue sample origin (normal subjects, SSc patients). Transcripts are listed according to A* = average of log₂ (RxG) of the two arrays, where R and G represent the fluorescence intensity of Cy5 (red) and Cy3 (green). Grouping of various transcripts allows the identification of the following main categories: genes encoding for cytoskeletal elements; genes encoding for proteins that play a role in regulation of actin polymerization; genes regulating detoxification of heavy metals (such as cadmium, zinc and mercury), essential metal homeostasis, protection against radiation and oxidative damage; genes encoding ribosomal proteins; and miscellanea. (b) A PDF file showing the list of all the Gene Ontology (GO) significant terms obtained by the analysis of the 199 differentially expressed genes. This list integrates that shown in Table 1 of the text, where only differentially expressed genes with more than two annotated genes on the array (N > 2) are reported.

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Giusti et al. Arthritis Research & Therapy 2006 8:R115   doi:10.1186/ar2002