Figure 5.

Arthritis-related gene clusters on chromosome (Chr.) 11. The peak at the Chr. 11, 81- to 83-megabase (Mb) (#4–6) includes Ccl and Slfn family clusters. An expanded view of this region in 2-Mb window is shown. Hierarchical clustering patterns of the expression levels are shown below. Ccl and Slfn genes are clearly clustered in specific narrow loci and augmented in arthritis. CC, Cysteine-Cysteine type; KS, interleukin-1 receptor antagonist-knockout mice; TS, human T-cell leukemia virus type I- transgenic mice; WT, wild-type mice.