Figure 4.

Identification of the H-2 gene cluster as one of the significantly activated gene clusters. The maximal gene density was mapped to the chromosome (Chr.) 17, 33- to 35-megabase (Mb) locus (#1–3), which corresponds to the H-2 gene cluster. Fold changes of the significantly changed genes are shown in a region of 2-Mb window. Hierarchical clustering of these genes is visualized below. Each column represents an RNA preparation from a different mouse strain, and each row represents an individual gene. Red represents expression levels greater than the median, and green represents those less than the median. The expression scale is shown at the bottom. KS, interleukin-1 receptor antagonist-knockout mice; MHC, major histocompatibility complex; TS, human T-cell leukemia virus type I- transgenic mice; WT, wild-type mice.