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Letter

Replication of association of the D-repeat polymorphism in asporin with osteoarthristis

Shiro Ikegawa1*, Shingo Kawamura1, Atsushi Takahashi2, Takahiro Nakamura2 and Naoyuki Kamatani2

Author Affiliations

1 Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108–8639, Japan

2 Laboratory for Statistical Analysis, SNP Research Center, RIKEN, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108–8639, Japan

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Arthritis Research & Therapy 2006, 8:403  doi:10.1186/ar1992


See related research by Ikegawa et al., http://arthritis-research.com/content/8/4/403

Published: 29 June 2006

First paragraph (this article has no abstract)

Rodriguez-Lopez and colleagues [1] describe a replication study of our previous association between osteoarthritis (OA) and asporin [2]. The authors were unable to find this association in the Spanish population and question the association we found in the Japanese population. Their report also contains an interpretation of two previous papers on the same topic [3,4] that differs from those of the original study authors. We have concerns about their interpretation of data and about the conclusions drawn.