Table 1

Examples of autoantigens involved in RNA metabolic processes

Autoantigen
Ribonucleoprotein complex
Target protein(s)
Subcellular localization
Process

Sm
U snRNP
Sm proteins
Nucleoplasm
Pre-mRNA splicing
Ro
Y RNP
Ro60
Cytoplasm
RNA quality control
La
La RNP
La protein
Nucleoplasm
Maturation RNA Pol III transcripts
Th/To
RNase MRP, RNase P
Rpp38, Rpp25, Rpp20
Nucleoli
Pre-rRNA processing
Su
RISC
Ago, Dicer
Cytoplasm
RNAi

RISC = RNA-induced silencing complex; RNP = ribonucleoprotein particle.

Pruijn Arthritis Research & Therapy 2006 8:110   doi:10.1186/ar1987