Table 2

IL-1F8 protein levels in mouse and human joint samples and in mouse skin

Samples

Patients/animals

IL-1F8 (pg/mg protein)

IL-1β (pg/mg protein)

Human synovium

OA (n = 4)

3.7 ± 1.4

3.6 ± 0.3

Inflammatory arthritis (n = 5)

3.9 ± 1.0

11.6 ± 5.7^a

Mouse joint

Naïve (n = 1)

2.8

2.3

Nonarthritic (n = 1)

2.7

4.5

CIA early^b (n = 3)

2.2 ± 0.3

16.6 ± 1.2^c

CIA late^b (n = 3)

4.5 ± 1.4

8.8 ± 0.8

Mouse skin

Control (n = 3)

761.7 ± 313.4

16 ± 3

PMA (n = 3)

14569.1 ± 3632.5^d

28 ± 3^d

IL-1F8 protein levels were determined using enzyme-linked immunosorbent assay. ^aP < 0.05 versus osteoparthritis (OA), as assessed using the Mann-Whitney test. ^bCollagen-induced arthritis (CIA) early: days 1–7 after the onset of arthritis; CIA late: days 8–21 after onset of arthritis. ^cP < 0.05 versus late CIA, as assessed using analysis of variance. ^dP < 0.05 versus control, as assessed using analysis of variance.

Magne et al. Arthritis Research & Therapy 2006 8:R80   doi:10.1186/ar1946