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The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis

Katsue Sunahori, Masahiro Yamamura*, Jiro Yamana, Kouji Takasugi, Masanori Kawashima, Hiroshi Yamamoto, Walter J Chazin, Yuichi Nakatani, Satoru Yui and Hirofumi Makino

Arthritis Research & Therapy 2006, 8:R69  doi:10.1186/ar1939