Table 3 |
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|
Renal histological assessment in 12-month old mice |
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|
Histology gradea |
||||||
|
|
||||||
|
0 |
I |
II |
III |
IV |
Total |
|
|
|
||||||
|
Apcs-/- |
8 (18) |
18 (41) |
12 (27) |
5 (11) |
1 (2) |
44 |
|
wt.DNase I. Apcs-/- |
4 (19) |
8 (38) |
5 (24) |
3 (14) |
1 (5) |
21 |
|
ash.DNase I. Apcs-/- |
4 (19) |
7 (33) |
5 (24) |
5 (24) |
0 (0) |
21 |
|
|
||||||
|
aValues represent the number of mice (%) scored within that grade of glomerular hypercellularity. Grades 0 to IV are as described in Materials and methods. ash.DNase I, actin-resistant, salt-resistant and hyperactive mutant of DNase I; wt.DNase I, wild-type DNase I. |
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|
Manderson et al. Arthritis Research & Therapy 2006 8:R68 doi:10.1186/ar1936 |
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