|
Correlations between rheumatoid factor or anti-CCP and IgG content in immune complexes and TNF-α inducing properties of immune complexes |
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| Correlation |
Study 1 (n = 15) |
Study 2 (n = 32) |
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|
|
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| r |
P |
r |
P |
|
|
|
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| RF/SF immune complexes |
||||
| IgG in SF precipitates/TNF-α induced by SF precipitates |
0.604 |
0.0239 |
0.503 |
0.0051 |
| RF/TNF-α induced by SF precipitates |
0.404 |
0.1310 (NS) |
0.594 |
0.001 |
| RF/IgG in SF precipitates |
0.729 |
0.0064 |
0.360 |
0.0449 |
| RF/serum immune complexes |
||||
| IgG in serum precipitates/TNF-α induced by serum precipitates |
0.171 |
NS |
-0.265 |
NS |
| RF/TNF-α induced by serum precipitates |
0.332 |
NS |
0.329 |
NS |
| RF/IgG in serum precipitates |
0.346 |
NS |
0.388 |
0.0308 |
| Anti-CCP/SF immune complexes |
||||
| Anti-CCP/TNF-α induced by SF precipitates |
ND |
ND |
0.043 |
NS |
| Anti-CCP/IgG in SF precipitates |
ND |
ND |
0.083 |
NS |
| Anti-CCP/serum immune complexes |
||||
| Anti-CCP/TNF-α induced by serum precipitates |
ND |
ND |
0.191 |
NS |
| Anti-CCP/IgG in serum precipitates |
ND |
ND |
0.246 |
NS |
|
CCP, cyclic citrullinated peptide; ND, not done; NS, not significant; RA, rheumatoid arthritis; RF, rheumatoid factor; SF, synovial fluid; TNF, tumour necrosis factor. | ||||
Mathsson et al. Arthritis Research & Therapy 2006 8:R64 doi:10.1186/ar1926 |
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