Table 1

Correlations between rheumatoid factor or anti-CCP and IgG content in immune complexes and TNF-α inducing properties of immune complexes

Correlation

Study 1 (n = 15)

Study 2 (n = 32)


r

P

r

P


RF/SF immune complexes

IgG in SF precipitates/TNF-α induced by SF precipitates

0.604

0.0239

0.503

0.0051

RF/TNF-α induced by SF precipitates

0.404

0.1310 (NS)

0.594

0.001

RF/IgG in SF precipitates

0.729

0.0064

0.360

0.0449

RF/serum immune complexes

IgG in serum precipitates/TNF-α induced by serum precipitates

0.171

NS

-0.265

NS

RF/TNF-α induced by serum precipitates

0.332

NS

0.329

NS

RF/IgG in serum precipitates

0.346

NS

0.388

0.0308

Anti-CCP/SF immune complexes

Anti-CCP/TNF-α induced by SF precipitates

ND

ND

0.043

NS

Anti-CCP/IgG in SF precipitates

ND

ND

0.083

NS

Anti-CCP/serum immune complexes

Anti-CCP/TNF-α induced by serum precipitates

ND

ND

0.191

NS

Anti-CCP/IgG in serum precipitates

ND

ND

0.246

NS


CCP, cyclic citrullinated peptide; ND, not done; NS, not significant; RA, rheumatoid arthritis; RF, rheumatoid factor; SF, synovial fluid; TNF, tumour necrosis factor.

Mathsson et al. Arthritis Research & Therapy 2006 8:R64   doi:10.1186/ar1926

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