Table 3 |
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|
Distribution of genotypes between affected and unaffected N2 mice at different loci linked to clinical phenotypes of collagen-induced arthritis |
|||||||
| Trait |
Locus |
Location (cM) |
Affected |
Unaffected |
LOD |
||
|
|
|||||||
| Homozygote for B10.Q |
Heterozygote |
Homozygote for B10.Q |
Heterozygote |
||||
|
|
|||||||
| Incidence at day 100 |
D1Mit161 |
27.0 |
36 (71%) |
15 (29%) |
70 (48%) |
75 (52%) |
2.8* |
| D11Mit70 |
54.0 |
30 (58%) |
21 (31%) |
49 (34%) |
96 (66%) |
2.7* |
|
| D11Mit99 |
59.5 |
35 (69%) |
16 (31%) |
50 (35%) |
95 (65%) |
4.0** |
|
| D11Mit360 |
64.0 |
37 (73%) |
14 (27%) |
46 (31%) |
99 (68%) |
4.1** |
|
| D11Mit258 |
65.0 |
36 (71%) |
15 (29%) |
49 (34%) |
96 (66%) |
4.1** |
|
| D11Mit333 |
66.0 |
36 (71%) |
15 (29%) |
48 (33%) |
97 (67%) |
4.1** |
|
| D11Mit181 |
69.0 |
37 (73%) |
14 (27%) |
48 (33%) |
97 (67%) |
4.1** |
|
| D11Mit214 |
70.0 |
39 (76%) |
12 (24%) |
55 (38%) |
90 (62%) |
4.0* |
|
|
|
|||||||
|
*Suggestive significance, **significant. |
|||||||
|
Liljander et al. Arthritis Research & Therapy 2006 8:R45 doi:10.1186/ar1901 |
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