Table 4 |
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|
Estimated pairwise haplotype frequencies in rheumatoid arthritis patients and healthy controls |
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|
Genes |
Haplotype |
UK Caucasian |
North Indian/Pakistani |
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|
|
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|
Control |
RA |
Pa |
Nodular RA |
P |
Control |
RA |
P |
||
|
|
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|
FCGR2A-FCGR3A |
131R-158F |
0.43 |
0.41 |
0.25 |
0.32 |
0.13 |
0.34 |
0.30 |
0.46 |
|
131R-158V |
0.11 |
0.11 |
0.16 |
0.11 |
0.15 |
||||
|
131H-158F |
0.27 |
0.22 |
0.22 |
0.36 |
0.34 |
||||
|
131H-158V |
0.19 |
0.26 |
0.30 |
0.19 |
0.21 |
||||
|
FCGR3A-FCGR3B |
158F-NA2 |
0.42 |
0.31 |
0.08 |
0.27 |
0.07 |
0.38 |
0.36 |
0.33 |
|
158F-NA1 |
0.28 |
0.32 |
0.27 |
0.34 |
0.29 |
||||
|
158V-NA2 |
0.24 |
0.31 |
0.37 |
0.19 |
0.25 |
||||
|
158V-NA1 |
0.06 |
0.06 |
0.09 |
0.10 |
0.11 |
||||
|
FCGR3B-FCGR2B |
NA2-1206G |
0.36 |
0.34 |
0.77 |
0.35 |
0.41 |
0.33 |
0.33 |
0.45 |
|
NA2-1206A |
0.29 |
0.27 |
0.30 |
0.24 |
0.28 |
||||
|
NA1-1206G |
0.31 |
0.33 |
0.26 |
0.37 |
0.37 |
||||
|
NA1-1206A |
0.04 |
0.06 |
0.09 |
0.06 |
0.03 |
||||
|
|
|||||||||
|
Pairwise haplotypes produced from four biallelic markers (FCGR2A-131H/R, FCGR3A-158F/V, FCGR3B-NA2/1 and FCGR2B-1206G/A) denoted in the order they occur at the FCGR locus. Thus, 131R-158F indicates a haplotype containing FCGR2A-131R and FCGR3A-158F alleles. aEmpirical P values obtained from a heterogeneity test statistic incorporated in the PM program after 1,000 permutations. RA, rheumatoid arthritis. |
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|
Morgan et al. Arthritis Research & Therapy 2006 8:R5 doi:10.1186/ar1847 |
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