Table 4

Estimated pairwise haplotype frequencies in rheumatoid arthritis patients and healthy controls

Genes

Haplotype

UK Caucasian

North Indian/Pakistani


Control

RA

Pa

Nodular RA

P

Control

RA

P


FCGR2A-FCGR3A

131R-158F

0.43

0.41

0.25

0.32

0.13

0.34

0.30

0.46

131R-158V

0.11

0.11

0.16

0.11

0.15

131H-158F

0.27

0.22

0.22

0.36

0.34

131H-158V

0.19

0.26

0.30

0.19

0.21

FCGR3A-FCGR3B

158F-NA2

0.42

0.31

0.08

0.27

0.07

0.38

0.36

0.33

158F-NA1

0.28

0.32

0.27

0.34

0.29

158V-NA2

0.24

0.31

0.37

0.19

0.25

158V-NA1

0.06

0.06

0.09

0.10

0.11

FCGR3B-FCGR2B

NA2-1206G

0.36

0.34

0.77

0.35

0.41

0.33

0.33

0.45

NA2-1206A

0.29

0.27

0.30

0.24

0.28

NA1-1206G

0.31

0.33

0.26

0.37

0.37

NA1-1206A

0.04

0.06

0.09

0.06

0.03


Pairwise haplotypes produced from four biallelic markers (FCGR2A-131H/R, FCGR3A-158F/V, FCGR3B-NA2/1 and FCGR2B-1206G/A) denoted in the order they occur at the FCGR locus. Thus, 131R-158F indicates a haplotype containing FCGR2A-131R and FCGR3A-158F alleles. aEmpirical P values obtained from a heterogeneity test statistic incorporated in the PM program after 1,000 permutations. RA, rheumatoid arthritis.

Morgan et al. Arthritis Research & Therapy 2006 8:R5   doi:10.1186/ar1847

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