Table 1 |
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|
Histological and biochemical characteristics of baseline values of human osteoarthritic cartilage for different treatment groups |
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| Parameter |
Indomethacin (10 μmol/l) |
Naproxen (300 μmol/l) |
Aceclofenac (0.03 μmol/l) |
Celecoxib (0.01 μmol/l) |
|
|
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| Age (years) |
70 ± 2 |
67 ± 3 |
63 ± 2 |
70 ± 3 |
| Sex (female/male) |
4/1 |
3/2 |
4/1 |
4/1 |
| Histological cartilage damage (Mankin grade) |
3 ± 1 |
4 ± 1 |
6 ± 2 |
5 ± 2 |
| Prostaglandin synthesis rate (nmol/hour per g) |
6.8 ± 2.3 |
3.4 ± 1.9 |
4.8 ± 0.9 |
5.5 ± 1.8 |
| % New prostaglandin release |
11 ± 2 |
13 ± 2 |
12 ± 2 |
11 ± 2 |
| % Total release |
9 ± 2 |
7 ± 2 |
5 ± 1 |
6 ± 1 |
| Prostaglandin content (mg/g) |
22 ± 2 |
19 ± 1 |
17 ± 6 |
19 ± 1 |
|
|
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|
Mastbergen et al. Arthritis Research & Therapy 2006 8:R2 doi:10.1186/ar1846 |
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