Table 3

Conditional logistic regression analyses of combinations of genes and antibodies
Combination of variables
 Pre-patients
 Controls
 OR
 95% CI

n
 %
 n
 %

PTPN22 CT+TT- + anti-CCP Abs-
 39
 45.3
 272
 78.4
 1.00
PTPN22 CT+TT+ + anti-CCP Abs-
 15
 17.5
 70
 20.2
 1.20
 0.62–2.35
PTPN22 CT+TT- + anti-CCP Abs+
 13
 15.1
 5
 1.4
 16.61
 4.68–58.97
PTPN22 CT+TT+ + anti-CCP Abs+
 19
 22.1
 0a
 0.0
 132.03a
 17.84–2720.91a







PTPN22 CT+TT- + IgG-RF-
 27
 48.2
 175
 76.1
 1.00
PTPN22 CT+TT+ + IgG-RF-
 19
 33.9
 46
 20.0
 2.47
 1.26–4.85
PTPN22 CT+TT- + IgG-RF+
 9
 16.1
 6
 2.6
 10.08
 3.00–33.94
PTPN22 CT+TT+ + IgG-RF+
 1
 1.8
 3
 1.3
 1.50
 0.15–14.84







PTPN22 CT+TT- + IgA-RF-
 23
 41.1
 171
 74.3
 1.00
PTPN22 CT+TT+ + IgA-RF-
 11
 19.6
 47
 20.4
 1.55
 0.69–3.49
PTPN22 CT+TT- + IgA-RF+
 13
 23.2
 10
 4.4
 9.23
 3.31–25.76
PTPN22 CT+TT+ + IgA-RF+
 9
 16.1
 2
 0.9
 21.42
 4.45–103.16







PTPN22 CT+TT- + IgM-RF-
 28
 50.0
 170
 73.9
 1.00
PTPN22 CT+TT+ + IgM-RF-
 16
 28.6
 46
 20.0
 1.97
 0.98–4.04
PTPN22 CT+TT- + IgM-RF+
 8
 14.3
 11
 4.8
 4.65
 1.65–13.13
PTPN22 CT+TT+ + IgM-RF+
 4
 7.1
 3
 1.3
 10.70
 1.78–64.23







PTPN22 CT+TT- + SE-
 24
 27.6
 86
 50.6
 1.00
PTPN22 CT+TT+ + SE-
 14
 16.1
 18
 10.6
 3.35
 1.34–8.26
PTPN22 CT+TT- + SE+
 28
 32.2
 54
 31.8
 2.12
 1.06–4.25
PTPN22 CT+TT+ + SE+
 21
 24.1
 12
 7.0
 7.85
 3.03–20.30

Results of conditional logistic regression analyses of carriage of the PTPN22 1858T variant (CT + TT), HLA shared epitope (SE), anti-cyclic citrullinated peptide antibodies (anti-CCP Abs) or rheumatoid factors (RFs) of IgG, IgM, or IgA isotype for the prediction of rheumatoid arthritis in individuals who later developed the disease and matched controls. aCalculations made with a hypothetical control individual positive for both the PTPN22 1858T variant and anti-CCP antibodies.

Johansson et al. Arthritis Research & Therapy 2006 8:R19   doi:10.1186/ar1868

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