|
Allele frequencies of the nine regulatory single nucleotide polymorphisms in extracellular matrix proteases |
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| Gene |
SNP |
Allele |
RA patients |
Controls |
OR |
p |
Sex-adjusted OR |
Change in transcriptiona |
|
|
||||||||
| MMP1 |
-1607 1G/2G |
2G |
47.8 |
48.2 |
0.98 |
0.8 |
0.96 |
Up |
| MMP2 |
-1306 C/T |
T |
24.5 |
20.3 |
1.27 |
0.01 |
1.27 |
Down |
| MMP3 |
-1171 6A/5A |
5A |
50.5 |
51.7 |
0.95 |
0.5 |
0.96 |
Up |
| MMP7 |
-181 A/G |
G |
43.8 |
45.3 |
0.94 |
0.4 |
0.95 |
Up |
| -153 C/T |
T |
5.0 |
5.1 |
0.99 |
0.9 |
0.98 |
Up |
|
| MMP9 |
-1562 C/T |
T |
14.3 |
13.6 |
1.05 |
0.6 |
1.02 |
Up |
| MMP13 |
-77 A/G |
A |
68.0 |
65.6 |
1.13 |
0.2 |
1.09 |
Up |
| PLAT |
-7351 C/T |
T |
36.4 |
32.1 |
1.21 |
0.03 |
1.20 |
Down |
| PAI-1 |
-675 5G/4G |
4G |
47.6 |
46.8 |
1.03 |
0.7 |
1.05 |
Up |
|
Frequency values for rheumatoid arthritis (RA) and controls are percentages. aReported up- or downregulation of gene expression determined by the mentioned allele. MMP, matrix metalloproteinase; OR, odds ratio; PAI, plasminogen activator inhibitor; PLAT, plasminogen activator, tissue type; SNP, single nucleotide polymorphism. | ||||||||
Rodriguez-Lopez et al. Arthritis Research & Therapy 2006 8:R1 doi:10.1186/ar1849 |
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