Table 1

Patterns of anti-Epstein–Barr virus (EBV) serologies observed in different disease states

Disease state

VCA

EBNA-1

EBNA-2

EA

References


Early, acute primary EBV infection

IgA, IgM

Undetectable

↑↑

EA-D

[45,66]

Primary infection (weeks to months)

IgG

EA-R

[45,67]

Latent EBV infection in healthy host

Stable IgG

Stable

Stable EA-R

[67]

Reactivation/EBV replication

↑↑ IgG

↑↑

[67-69,117]

Nasopharyngeal carcinomaa

↑↑ IgG, IgA

↑ IgG, IgA

[70,118-120]

Burkitt's lymphomaa

↑↑ IgG

↑↑

[70,121]

Multiple sclerosisa

↑↑

[111,112]

Systemic lupus erythematosusa

[113,114]

Rheumatoid arthritis

[82-86,122]


EA, EBV early antigen; EA-D, EBV early antigen – diffuse; EA-R, EBV early antigen – restricted; EBNA, EBV nuclear antigen; VCA, EBV viral capsid antigen. aAbnormalities observed before disease onset.

Costenbader and Karlson Arthritis Research & Therapy 2006 8:204   doi:10.1186/ar1893