Table 1

Classification of inhibitory oligodeoxynucleotides

Feature

Class B

Class R

Cell specificity

All TLR9⁺ cells

MZ-B, DC, MF

Potency

Nanomolar

Nanomolar

Structure

Linear–primary

Secondary

Backbone

PS

PS or SOS

Effect on BCR signaling

No

Yes(?) in anti-dsDNA B cells

Inhibitory activity in animal lupus

Yes [132]

Yes [125]

Prototype

BCR, B cell receptor for antigen; DC, dendritic cell; ds, double stranded; MF, macrophages; MZ, marginal zone; PS, phosphorothioate; SOS, chimeric – phosphorothioate-phosphodiester-phosphorothioate; TLR, Toll-like receptor.

Lenert Arthritis Research & Therapy 2006 8:203   doi:10.1186/ar1888