Figure 3.

Effect of EPA on the production of eicosanoids and inflammatory cytokines. *Three different synthases (PGE, PGI, and TX synthase), each with different enzyme kinetic characteristics. -, inhibition; AA, arachidonic acid; COX, cyclo-oxygenase; EPA, eicosapentaenoic acid; IL, interleukin; LT, leukotriene; NSAID, nonsteroidal anti-inflammatory drug; PG, prostaglandin; TNF, tumour necrosis factor; TX, thromboxane.