Table 2

T cell directed therapies in rheumatoid arthritis

Intervention

Examples


Reduction in T cell number or function

Total lymphoid irradiation

Thoracic duct drainage

Immunosuppressive drugs

Glucocorticoids

Methotrexate

Leflunomide

Cyclosporine

FK 506 (tacrolimus)

Rapamycin (sirolimus)

Biologicals

TCR vaccination

mAbs to T cell surface receptors

mAbs to surface receptors on cells interacting with T cells

Cytokines, mAbs to cytokines

Inhibitors of T cell/APC interactions


APC, antigen-presenting cell; mAb, monoclonal antibody; TCR, T-cell receptor.

Skapenko et al. Arthritis Research & Therapy 2005 7(Suppl 2):S4-S14   doi:10.1186/ar1703