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T cell directed therapies in rheumatoid arthritis |
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| Intervention |
Examples |
|
|
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| Reduction in T cell number or function |
Total lymphoid irradiation |
| Thoracic duct drainage |
|
| Immunosuppressive drugs |
Glucocorticoids |
| Methotrexate |
|
| Leflunomide |
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| Cyclosporine |
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| FK 506 (tacrolimus) |
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| Rapamycin (sirolimus) |
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| Biologicals |
TCR vaccination |
| mAbs to T cell surface receptors |
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| mAbs to surface receptors on cells interacting with T cells |
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| Cytokines, mAbs to cytokines |
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| Inhibitors of T cell/APC interactions |
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APC, antigen-presenting cell; mAb, monoclonal antibody; TCR, T-cell receptor. | |
Skapenko et al. Arthritis Research & Therapy 2005 7(Suppl 2):S4 doi:10.1186/ar1703 |
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