Table 2 |
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T cell directed therapies in rheumatoid arthritis |
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|
Intervention |
Examples |
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|
|
|
Reduction in T cell number or function |
Total lymphoid irradiation |
|
Thoracic duct drainage |
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|
Immunosuppressive drugs |
Glucocorticoids |
|
Methotrexate |
|
|
Leflunomide |
|
|
Cyclosporine |
|
|
FK 506 (tacrolimus) |
|
|
Rapamycin (sirolimus) |
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|
Biologicals |
TCR vaccination |
|
mAbs to T cell surface receptors |
|
|
mAbs to surface receptors on cells interacting with T cells |
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|
Cytokines, mAbs to cytokines |
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|
Inhibitors of T cell/APC interactions |
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|
|
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|
APC, antigen-presenting cell; mAb, monoclonal antibody; TCR, T-cell receptor. |
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Skapenko et al. Arthritis Research & Therapy 2005 7(Suppl 2):S4 doi:10.1186/ar1703 |
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